ISO 14644 Cleanrooms & Aseptic Pharma Fill-Finish, EN 1822 HEPA/ULPA MPPS & Laminar Flow
EN 1822 HEPA Filter MPPS Penetration, LRV & Hood CFM
Calculate Most Penetrating Particle Size (MPPS) Penetration (%), Filter Log-Reduction Value LRV, ISO Class 5 Unidirectional Hood Airflow (m³/h), and Fan Supply (CFM).
HEPA filters do NOT act like sieves—0.05 um viruses diffuse into fibers and 1 um dust impacts, making 0.15–0.25 um MPPS particles the hardest to trap and a 1.2% gel-seal leak a 240x contamination breach!
**EN `1822` / ISO `29463` Cleanroom HEPA (`H13 = 99.95%`, `H14 = 99.995%`) and ULPA (`U15 = 99.9995%`) Fiberglass Pleated Filters** test efficiency right at the **Most Penetrating Particle Size (`MPPS`, `0.15–0.25` um)** where Brownian diffusion (`dominant < 0.1` um) and inertial impaction/interception (`dominant > 0.3` um) hit their combined valley! From **Integral MPPS Capture Efficiency `eta` (`%`)**, **MPPS Penetration `P = 100 - eta`** (`%`) and **Decadic Log-Reduction Value `LRV = -log10(P / 100)`** (`e.g. H14 P = 0.005% -> LRV = 4.30` = `1` particle in `20,000`!) govern sterile sterility assurance, while **EU GMP Grade A / ISO Class 5 Unidirectional Laminar-Flow Hoods** (`Width W` m x `Depth D` m) maintain **`v_f = 0.45` m/s (`+/-20%`, `90` fpm)** sweep velocity, requiring **Supply Airflow `Q = W * D * v_f * 3,600`** (`m³/h`, or **`(W * D * v_f) * 2,118.88` CFM**)!
Verify on a `1.8` m Sterile Vial-Filling `H14` Laminar-Flow Workstation—`H14`_MPPS_Efficiency `eta` = 99.995% (B2), Hood_Width `W` = 1.80 m (B3), Hood_Depth `D` = 0.75 m (B4), and Target_Face_Velocity `v_f` = 0.45 m/s (B5): MPPS Penetration equals **`0.0050%`** (E2), Filter Log-Reduction Value equals **`4.30` logs** (E3), Unidirectional Supply Flow equals **`2,187.0` m³/h** (E4), or **`1,287.2` CFM** on the FFU EC-blower schedule (E5)!
| EN 1822 H14 HEPA & ISO 5 Hood KPI (1.80 m x 0.75 m Face) | Formula | Verified Output |
|---|---|---|
| MPPS Aerosol Penetration (%) | 100 - MPPS_Capture_Efficiency_Pct | 0.0050% H14 (1.2000% knife-edge leak!) |
| Filter Log-Reduction Value (LRV) | -LOG10((100 - Efficiency_Pct) / 100) | 4.30 logs (1.92 logs = 240x particle pass!) |
| Unidirectional Airflow (m³/h) | Width_m * Depth_m * Face_Vel_m_s * 3600 | 2,187.0 m³/h (1,360.8 m³/h @ 0.28 m/s) |
| FFU Supply Airflow (CFM) | (Width_m * Depth_m * Face_Vel_m_s) * 2118.88 | 1,287.2 CFM (800.9 CFM stalled sweep!) |
EN 1822 MPPS Penetration, Log-Reduction LRV & Unidirectional Face-Flow Formula
Validate `MPPS_Efficiency eta` in `[85.0, 99.999995]`%, `Hood_Width W` in `[0.3, 10.0]` m, `Hood_Depth D` in `[0.3, 5.0]` m, and `Face_Velocity v_f` in `[0.15, 1.20]` m/s!
=LET(ef_p, B2, wd_m, B3, dp_m, B4, vf_s, B5, IF(OR(ef_p < 85, ef_p > 99.999995, wd_m < 0.3, wd_m > 10, dp_m < 0.3, dp_m > 5, vf_s < 0.15, vf_s > 1.2), "Invalid HEPA Input", ROUND((wd_m * dp_m * vf_s) * 2118.88, 1)))Unseated Gel-Seal Bypass (`eta = 98.8%`) + Loaded Pre-Filter (`v_f = 0.28` m/s) PAO Audit Check
Nick a polyurethane gel-knife gasket during installation (`PAO` photometer scan drops effective capture to `B2 = 98.8%`) while a clogged pre-filter drags face velocity down to `B5 = 0.28` m/s (`< 0.36` m/s GMP minimum!): Penetration E2 explodes **`240-fold` to `1.20%`** (`LRV` E3 collapses from `4.30` to **`1.92` logs**!) while `800.9` CFM flow (E5) lets operator room wakes eddy backward into open sterile vials!
=IF(ISTEXT(E5), E5, ROUND(-LOG10((100 - B2) / 100), 2))Try the example
Use the original values or change them to test your understanding.