Healthcare & Clinical Calculators
UKELD Score (UK Model for End-Stage Liver Disease & >= 49 Listing Cutoff)
Calculate NHS Blood and Transplant’s SI-unit UKELD score = 5.395*LN(INR) + 1.485*LN(Creat_µmol_L) + 3.130*LN(Bili_µmol_L) - 81.565*LN(Na_mmol_L) + 435 and >= 49 transplant eligibility.
Native SI micromolar liver transplant prioritization with hyponatremia built directly into the log-linear equation!
Whereas US UNOS MELD uses conventional mg/dL units, Kerri Barber et al. (Transplantation, 2011; NHS Blood and Transplant) derived UKELD directly in SI laboratory units—incorporating serum sodium’s profound prognostic weight (-81.565 * LN(Na)) from the outset: UKELD = 5.395 * LN(MAX(INR, 1)) + 1.485 * LN(Creatinine_µmol_L) + 3.130 * LN(MAX(Bilirubin_µmol_L, 1)) - 81.565 * LN(Sodium_mmol_L) + 435!
Under NHS liver allocation criteria, UKELD >= 49 predicts > 9% 1-year chronic liver disease mortality—matching 1-year post-transplant mortality and establishing minimum transplant waitlist eligibility! Check decompensated cirrhosis (INR = 1.8, Creatinine = 115 µmol/L, Bilirubin = 85 µmol/L, Sodium = 131 mmol/L): UKELD = 61.5 (>= 49 High Priority), vs. 49.2 borderline threshold for compensated disease (INR = 1.1, Cr = 80, Bili = 22, Na = 139)!
| SI Cirrhosis Labs [INR, Cr µmol/L, Bili µmol/L, Na mmol/L] | UKELD Score | NHS Transplant Eligibility (>= 49) |
|---|---|---|
| [1.1, 80, 22, 139] — Borderline Cirrhosis | 49.2 | Meets Minimum UKELD >= 49 Listing Threshold |
| [1.8, 115, 85, 131] — Decompensated Hyponatremic | 61.5 | High 1-Year Mortality (> 60 Urgent Priority) |
| Invalid Zero/Negative Lab Value | "Invalid UKELD Labs" | Logarithm Positivity Guard |
UKELD Continuous SI Liver Transplant Score
Evaluates 5.395*LN(MAX(B2, 1)) + 1.485*LN(B3) + 3.130*LN(MAX(B4, 1)) - 81.565*LN(B5) + 435 across INR B2, creatinine B3 (µmol/L), bilirubin B4 (µmol/L), and serum sodium B5 (mmol/L).
=IF(OR(B2 <= 0, B3 <= 0, B4 <= 0, B5 <= 0), "Invalid UKELD Labs", ROUND(5.395 * LN(MAX(B2, 1)) + 1.485 * LN(B3) + 3.13 * LN(MAX(B4, 1)) - 81.565 * LN(B5) + 435, 1))NHS Blood & Transplant UKELD >= 49 Listing Eligibility
Classifies UKELD scores below 49 (medical management), 49–59.9 (transplant listing eligible), and >= 60 (high waitlist mortality).
=IF(OR(B2 <= 0, B3 <= 0, B4 <= 0, B5 <= 0), "Invalid UKELD Labs", IF(5.395 * LN(MAX(B2, 1)) + 1.485 * LN(B3) + 3.13 * LN(MAX(B4, 1)) - 81.565 * LN(B5) + 435 >= 60, "High Waitlist Mortality Risk (UKELD >= 60)", IF(5.395 * LN(MAX(B2, 1)) + 1.485 * LN(B3) + 3.13 * LN(MAX(B4, 1)) - 81.565 * LN(B5) + 435 >= 49, "Transplant Listing Eligible (UKELD >= 49)", "Below Minimum Listing Cutoff (UKELD < 49)")))Try the example
Use the original values or change them to test your understanding.